Ontology highlight
ABSTRACT:
SUBMITTER: Zhang R
PROVIDER: S-EPMC6614116 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
iScience 20190621
Both caloric restriction (CR) and mitochondrial proteostasis are linked to longevity, but how CR maintains mitochondrial proteostasis in mammals remains elusive. MicroRNAs (miRNAs) are well known for gene silencing in cytoplasm and have recently been identified in mitochondria, but knowledge regarding their influence on mitochondrial function is limited. Here, we report that CR increases miRNAs, which are required for the CR-induced activation of mitochondrial translation, in mouse liver. The ab ...[more]