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Transcriptional Regulation of Autophagy: Mechanisms and Diseases.

ABSTRACT: Macro (Autophagy) is a catabolic process that relies on the cooperative function of two organelles: the lysosome and the autophagosome. The recent discovery of a transcriptional gene network that co-regulates the biogenesis and function of these two organelles, and the identification of transcription factors, miRNAs and epigenetic regulators of autophagy, demonstrated that this catabolic process is controlled by both transcriptional and post-transcriptional mechanisms. In this review article, we discuss the nuclear events that control autophagy, focusing particularly on the role of the MiT/TFE transcription factor family. In addition, we will discuss evidence suggesting that the transcriptional regulation of autophagy could be targeted for the treatment of human genetic diseases, such as lysosomal storage disorders (LSDs) and neurodegeneration.

SUBMITTER: Di Malta C

PROVIDER: S-EPMC6614182 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Transcriptional Regulation of Autophagy: Mechanisms and Diseases.

Di Malta Chiara C Cinque Laura L Settembre Carmine C

Frontiers in cell and developmental biology 20190702

Macro (Autophagy) is a catabolic process that relies on the cooperative function of two organelles: the lysosome and the autophagosome. The recent discovery of a transcriptional gene network that co-regulates the biogenesis and function of these two organelles, and the identification of transcription factors, miRNAs and epigenetic regulators of autophagy, demonstrated that this catabolic process is controlled by both transcriptional and post-transcriptional mechanisms. In this review article, we ...[more]

PMID: 31312633

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