Ontology highlight
ABSTRACT:
SUBMITTER: Tang J
PROVIDER: S-EPMC6614366 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Tang Jing J Gautam Prson P Gupta Abhishekh A He Liye L Timonen Sanna S Akimov Yevhen Y Wang Wenyu W Szwajda Agnieszka A Jaiswal Alok A Turei Denes D Yadav Bhagwan B Kankainen Matti M Saarela Jani J Saez-Rodriguez Julio J Wennerberg Krister K Aittokallio Tero T
NPJ systems biology and applications 20190708
Cancer cells with heterogeneous mutation landscapes and extensive functional redundancy easily develop resistance to monotherapies by emerging activation of compensating or bypassing pathways. To achieve more effective and sustained clinical responses, synergistic interactions of multiple druggable targets that inhibit redundant cancer survival pathways are often required. Here, we report a systematic polypharmacology strategy to predict, test, and understand the selective drug combinations for ...[more]