Ontology highlight
ABSTRACT:
SUBMITTER: Wu X
PROVIDER: S-EPMC6614418 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Scientific reports 20190708 1
mTOR signaling pathway is deregulated in most cancers and uncontrolled cell cycle progression is a hallmark of cancer cell. However, the precise molecular mechanisms of the regulation of DNA replication and chromatin metabolism by mTOR signaling are largely unknown. We herein report that mTOR signaling promotes the loading of MCM2-7 helicase onto chromatin and upregulates DNA replication licensing factor CDC6. Pharmacological inhibition of mTOR kinase resulted in CHK1 checkpoint activation and d ...[more]