Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC6614601 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Zhang Yi Y Bertulat Bianca B Tencer Adam H AH Ren Xiaojun X Wright Gregory M GM Black Joshua J Cardoso M Cristina MC Kutateladze Tatiana G TG
iScience 20190625
Phase separation can produce local structures with specific functionality in the cell, and in the nucleus, this can lead to chromatin reorganization. Microrchidia 3 (MORC3) is a human ATPase that has been implicated in autoimmune disorders and cancer. Here, we show that MORC3 forms phase-separated condensates with liquid-like properties in the cell nucleus. Fluorescence live-cell imaging reveals that the MORC3 condensates are heterogeneous and undergo dynamic morphological changes during the cel ...[more]