IL-4/IL-4R and IL-6/IL-6R genetic variations and gastric cancer risk in the Chinese population.

ABSTRACT:

Objective

The IL-4/IL-4R and IL-6/IL-6R signaling pathways are involved in immune response and play roles in gastric carcinogenesis. To investigate the association between IL-4/IL-4R and IL-6/IL-6R genetic variations and gastric cancer risk, and their prognostic values, we performed a case-control study. The genotypes of the genetic variations were detected using a Mass-array platform. The Helicobacter pylori infection status was determined using a commercial H. pylori immunogold testing kit. We found that the IL-6 rs1800796 G allele was associated with an increased risk of gastric cancer (GG vs. CC: OR_adjusted = 2.20, 95% CI = 1.33-3.63; GG/CG vs. CC: OR_adjusted = 1.41, 95% CI = 1.09-1.82). The stratified analy

SUBMITTER: He B 

PROVIDER: S-EPMC6614618 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature