SPINK1 Defines a Molecular Subtype of Prostate Cancer in Men with More Rapid Progression in an at Risk, Natural History Radical Prostatectomy Cohort.

ABSTRACT:

Purpose

Prostate cancer is clinically and molecularly heterogeneous. We determined the prognosis of men with ERG-ETS fusions and SPINK1 over expression.

Materials and methods

Men were identified with intermediate or high risk localized prostate cancer treated with radical prostatectomy and no therapy before metastasis. A case-cohort design sampled a cohort (262) enriched with metastasis from the entire cohort and a cohort (213) enriched with metastasis from patients with biochemical recurrence. We analyzed transcriptomic profiles and subtyped tumors as m-ERG⁺, m-ETS⁺, m-SPINK1⁺ or Triple Negative (m-ERG^─/m-ETS^─/m-SPINK1^─), and multivariable logistic regression analyses, Kaplan-Meier and multivariable Cox model

SUBMITTER: Johnson MH 

PROVIDER: S-EPMC6615051 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature