Unknown

Dataset Information

0

Evaluation of serum free fatty acids in chronic renal failure: evidence from a rare case with undetectable serum free fatty acids and population data.


ABSTRACT: BACKGROUND:Free fatty acid (FFA) accumulation in proximal tubules plays a fundamental role in the progress of kidney disease. Here, we reported a rare case with undetectable serum FFAs and further evaluated the changes of serum FFAs in patients with chronic renal failure (CRF). METHODS:We analyzed the clinical data of a rare case and 574 CRF patients. The mRNA expression of lipoprotein lipase (LPL), hepatic lipase (HL) and fatty acid synthase (FASN) were determined in the rare case and 30 age-matched healthy males with qPCR. RESULTS:This rare case had serious proteinuria, hyperglycemia, lipid disorders and bilateral renal glomerular filtration dysfunction. Compared with healthy males, this case showed a 1.49-fold increase of LPL expression (P??0.05). In total, 21.6% of CRF patients showed abnormal FFAs. Biochemical parameters such as blood urea nitrogen (BUN) and creatinine (CREA) significantly differed among groups with low-, normal- or high-level-FFAs. Moreover, serum FFAs was found to be associated with BUN. FFAs decreased in the group with higher BUN (>?17.4?mmol/L) and in the group with lower estimated glomerular filtration rate (eGFR) (

SUBMITTER: Liu ZX 

PROVIDER: S-EPMC6615299 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

altmetric image

Publications

Evaluation of serum free fatty acids in chronic renal failure: evidence from a rare case with undetectable serum free fatty acids and population data.

Liu Zhen-Xian ZX   Hong Qian Q   Peng Ding-Hui DH   Yang Ying Y   Yu Wen-Li WL   Shui Hua H   Zhou Xin X   Liu Song-Mei SM  

Lipids in health and disease 20190708 1


<h4>Background</h4>Free fatty acid (FFA) accumulation in proximal tubules plays a fundamental role in the progress of kidney disease. Here, we reported a rare case with undetectable serum FFAs and further evaluated the changes of serum FFAs in patients with chronic renal failure (CRF).<h4>Methods</h4>We analyzed the clinical data of a rare case and 574 CRF patients. The mRNA expression of lipoprotein lipase (LPL), hepatic lipase (HL) and fatty acid synthase (FASN) were determined in the rare cas  ...[more]

Similar Datasets

| S-EPMC8727366 | biostudies-literature
| S-EPMC10740773 | biostudies-literature
| S-EPMC6779572 | biostudies-literature
| S-EPMC8547188 | biostudies-literature
| S-EPMC3157662 | biostudies-literature
| S-EPMC5454509 | biostudies-literature
2012-05-01 | E-GEOD-26885 | biostudies-arrayexpress
| S-EPMC6173776 | biostudies-literature
| S-EPMC1576090 | biostudies-literature
| S-EPMC7926759 | biostudies-literature