Vascular Burden Score Impacts Cognition Independent of Amyloid PET and MRI Measures of Alzheimer's Disease and Vascular Brain Injury.
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ABSTRACT:
SUBMITTER: DeCarli C
PROVIDER: S-EPMC6615551 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
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Vascular Burden Score Impacts Cognition Independent of Amyloid PET and MRI Measures of Alzheimer's Disease and Vascular Brain Injury.
DeCarli Charles C Villeneuve Sylvia S Maillard Pauline P Harvey Danielle D Singh Baljeet B Carmichael Owen O Fletcher Evan E Olichney John J Farias Sarah S Jagust William W Reed Bruce B Mungas Dan D
Journal of Alzheimer's disease : JAD 20190101 1
<h4>Background/objective</h4>To determine the impact of vascular burden on rates of decline in episodic memory and executive function. We hypothesize that greater vascular burden will have an additive negative impact on cognition after accounting for baseline cognitive impairment, positron emission tomography (PET) amyloid burden, and magnetic resonance imaging (MRI) measures.<h4>Methods</h4>Individuals were followed an average of 5 years with serial cognitive assessments. Predictor variables in ...[more]
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