Ontology highlight
ABSTRACT:
SUBMITTER: Ficarelli M
PROVIDER: S-EPMC6615859 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Ficarelli Mattia M Wilson Harry H Pedro Galão Rui R Mazzon Michela M Antzin-Anduetza Irati I Marsh Mark M Neil Stuart Jd SJ Swanson Chad M CM
eLife 20190709
CpG dinucleotides are suppressed in most vertebrate RNA viruses, including HIV-1, and introducing CpGs into RNA virus genomes inhibits their replication. The zinc finger antiviral protein (ZAP) binds regions of viral RNA containing CpGs and targets them for degradation. ZAP does not have enzymatic activity and recruits other cellular proteins to inhibit viral replication. We found that KHNYN, a protein with no previously known function, interacts with ZAP. KHNYN overexpression selectively inhibi ...[more]