Ontology highlight
ABSTRACT:
SUBMITTER: Chamoun K
PROVIDER: S-EPMC6615973 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Chamoun Kamal K Milton Denái R DR Ledesma Celina C Young Ken H KH Jabbour Elias J EJ Alatrash Gheath G Anderlini Paolo P Bashir Qaiser Q Ciurea Stefan O SO Marin David D Molldrem Jeffrey J JJ Olson Amanda L AL Oran Betul B Popat Uday R UR Rondon Gabriela G Champlin Richard E RE Gulbis Alison M AM Khouri Issa F IF
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20190301 7
Although bortezomib and rituximab have synergistic activity in patients with lymphoma and both can attenuate graft-versus-host disease (GVHD), the drugs have not been used together in patients undergoing allogeneic stem cell transplantation (alloSCT). In this phase I/II trial, we assessed the safety and activity of bortezomib added to the rituximab (R) plus BEAM (carmustine, etoposide, cytarabine, melphalan) regimen in patients with relapsed lymphoma undergoing alloSCT. Primary GVHD prophylaxis ...[more]