New roles for dopamine D₂ and D₃ receptors in pancreatic beta cell insulin secretion.

ABSTRACT: Although long-studied in the central nervous system, there is increasing evidence that dopamine (DA) has important roles in the periphery including in metabolic regulation. Insulin-secreting pancreatic β-cells express the machinery for DA synthesis and catabolism, as well as all five DA receptors. In these cells, DA functions as a negative regulator of glucose-stimulated insulin secretion (GSIS), which is mediated by DA D₂-like receptors including D₂ (D2R) and D₃ (D3R) receptors. However, the fundamental mechanisms of DA synthesis, storage, release, and signaling in pancreatic β-cells and their functional relevance in vivo remain poorly understood. Here, we assessed the roles of the DA precursor L-DOPA in β-cell DA synthesis and release in conjunction with

SUBMITTER: Farino ZJ 

PROVIDER: S-EPMC6616020 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature