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The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution.

ABSTRACT: Single-cell gene expression analyses of mammalian tissues have uncovered profound stage-specific molecular regulatory phenomena that have changed the understanding of unique cell types and signaling pathways critical for lineage determination, morphogenesis, and growth. We discuss here the case for a Pediatric Cell Atlas as part of the Human Cell Atlas consortium to provide single-cell profiles and spatial characterization of gene expression across human tissues and organs. Such data will complement adult and developmentally focused HCA projects to provide a rich cytogenomic framework for understanding not only pediatric health and disease but also environmental and genetic impacts across the human lifespan.

SUBMITTER: Taylor DM 

PROVIDER: S-EPMC6616346 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution.

Taylor Deanne M DM   Aronow Bruce J BJ   Tan Kai K   Bernt Kathrin K   Salomonis Nathan N   Greene Casey S CS   Frolova Alina A   Henrickson Sarah E SE   Wells Andrew A   Pei Liming L   Jaiswal Jyoti K JK   Whitsett Jeffrey J   Hamilton Kathryn E KE   MacParland Sonya A SA   Kelsen Judith J   Heuckeroth Robert O RO   Potter S Steven SS   Vella Laura A LA   Terry Natalie A NA   Ghanem Louis R LR   Kennedy Benjamin C BC   Helbig Ingo I   Sullivan Kathleen E KE   Castelo-Soccio Leslie L   Kreigstein Arnold A   Herse Florian F   Nawijn Martijn C MC   Koppelman Gerard H GH   Haendel Melissa M   Harris Nomi L NL   Rokita Jo Lynne JL   Zhang Yuanchao Y   Regev Aviv A   Rozenblatt-Rosen Orit O   Rood Jennifer E JE   Tickle Timothy L TL   Vento-Tormo Roser R   Alimohamed Saif S   Lek Monkol M   Mar Jessica C JC   Loomes Kathleen M KM   Barrett David M DM   Uapinyoying Prech P   Beggs Alan H AH   Agrawal Pankaj B PB   Chen Yi-Wen YW   Muir Amanda B AB   Garmire Lana X LX   Snapper Scott B SB   Nazarian Javad J   Seeholzer Steven H SH   Fazelinia Hossein H   Singh Larry N LN   Faryabi Robert B RB   Raman Pichai P   Dawany Noor N   Xie Hongbo Michael HM   Devkota Batsal B   Diskin Sharon J SJ   Anderson Stewart A SA   Rappaport Eric F EF   Peranteau William W   Wikenheiser-Brokamp Kathryn A KA   Teichmann Sarah S   Wallace Douglas D   Peng Tao T   Ding Yang-Yang YY   Kim Man S MS   Xing Yi Y   Kong Sek Won SW   Bönnemann Carsten G CG   Mandl Kenneth D KD   White Peter S PS  

Developmental cell 20190328 1

Single-cell gene expression analyses of mammalian tissues have uncovered profound stage-specific molecular regulatory phenomena that have changed the understanding of unique cell types and signaling pathways critical for lineage determination, morphogenesis, and growth. We discuss here the case for a Pediatric Cell Atlas as part of the Human Cell Atlas consortium to provide single-cell profiles and spatial characterization of gene expression across human tissues and organs. Such data will comple  ...[more]

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