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TLR4/NF-?B signaling pathway gene single nucleotide polymorphisms alter gene expression levels and affect ARDS occurrence and prognosis outcomes.

ABSTRACT: BACKGROUND:To study the occurrence and prognosis of acute respiratory distress syndrome (ARDS) using single nucleotide polymorphisms (SNPs) of TNF-? rs1800629, IL-6 rs1800796, and MyD88 rs7744 loci in the TLR4/NF-?B pathway. METHODS:Genotypes were analyzed for TNF-? rs1800629, IL-6 rs1800796, and MyD88 rs7744 loci. Plasma TNF-? and IL-6 levels and MyD88 mRNA expression in peripheral blood mononuclear cells (PBMCs) of 300 ARDS patients and 300 non-ARDS patients (control group) were examined. The patients were followed up for 60 days, and the prognosis outcome was recorded. RESULTS:The TNF-? rs1800629 locus A allele and the IL-6 rs1800796 locus G allele were found to be risk factors for ARDS (adjusted OR?=?1.452, 95% CI: 1.211-1.689, P?

SUBMITTER: Ding Y 

PROVIDER: S-EPMC6617146 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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TLR4/NF-κB signaling pathway gene single nucleotide polymorphisms alter gene expression levels and affect ARDS occurrence and prognosis outcomes.

Ding Yueping Y   Feng Qijia Q   Chen Jianshi J   Song Jia J  

Medicine 20190601 26

<h4>Background</h4>To study the occurrence and prognosis of acute respiratory distress syndrome (ARDS) using single nucleotide polymorphisms (SNPs) of TNF-α rs1800629, IL-6 rs1800796, and MyD88 rs7744 loci in the TLR4/NF-κB pathway.<h4>Methods</h4>Genotypes were analyzed for TNF-α rs1800629, IL-6 rs1800796, and MyD88 rs7744 loci. Plasma TNF-α and IL-6 levels and MyD88 mRNA expression in peripheral blood mononuclear cells (PBMCs) of 300 ARDS patients and 300 non-ARDS patients (control group) were  ...[more]

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