TLR4/NF-?B signaling pathway gene single nucleotide polymorphisms alter gene expression levels and affect ARDS occurrence and prognosis outcomes.
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ABSTRACT:
SUBMITTER: Ding Y
PROVIDER: S-EPMC6617146 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Publications
TLR4/NF-κB signaling pathway gene single nucleotide polymorphisms alter gene expression levels and affect ARDS occurrence and prognosis outcomes.
Ding Yueping Y Feng Qijia Q Chen Jianshi J Song Jia J
Medicine 20190601 26
<h4>Background</h4>To study the occurrence and prognosis of acute respiratory distress syndrome (ARDS) using single nucleotide polymorphisms (SNPs) of TNF-α rs1800629, IL-6 rs1800796, and MyD88 rs7744 loci in the TLR4/NF-κB pathway.<h4>Methods</h4>Genotypes were analyzed for TNF-α rs1800629, IL-6 rs1800796, and MyD88 rs7744 loci. Plasma TNF-α and IL-6 levels and MyD88 mRNA expression in peripheral blood mononuclear cells (PBMCs) of 300 ARDS patients and 300 non-ARDS patients (control group) were ...[more]
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