Ontology highlight
ABSTRACT:
SUBMITTER: Hill M
PROVIDER: S-EPMC6617385 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Hill Marcus M Cunningham Richard N RN Hathout Rania M RM Johnston Christopher C Hardy John G JG Migaud Marie E ME
Journal of functional biomaterials 20190613 2
Tobramycin is a potent antimicrobial aminoglycoside and its effective delivery by encapsulation within nanoparticle carriers could increase its activity against infections through a combination of sustained release and enhanced uptake. Effective antimicrobial therapy against a clinically relevant model bacteria (<i>Pseudomonas aeruginosa</i>) requires sufficient levels of therapeutic drug to maintain a drug concentration above the microbial inhibitory concentration (MIC) of the bacteria. Previou ...[more]