Ontology highlight
ABSTRACT:
SUBMITTER: Li LZ
PROVIDER: S-EPMC6617495 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Li Ling-Zhu LZ Yin Ning N Li Xue-Yan XY Miao Yanying Y Cheng Shuo S Li Fang F Zhao Guo-Li GL Zhong Shu-Min SM Wang Xin X Yang Xiong-Li XL Wang Zhongfeng Z
Neuroscience bulletin 20190319 4
Ras-related C3 botulinum toxin substrate 1 (Rac1), a member of the Rho GTPase family which plays important roles in dendritic spine morphology and plasticity, is a key regulator of cytoskeletal reorganization in dendrites and spines. Here, we investigated whether and how Rac1 modulates synaptic transmission in mouse retinal ganglion cells (RGCs) using selective conditional knockout of Rac1 (Rac1-cKO). Rac1-cKO significantly reduced the frequency of AMPA receptor-mediated miniature excitatory pos ...[more]