Ontology highlight
ABSTRACT:
SUBMITTER: Tufegdzic Vidakovic A
PROVIDER: S-EPMC6617506 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Methods (San Diego, Calif.) 20190213
Transcribing RNA polymerase II (RNAPII) is decorated by a plethora of post-translational modifications that mark different stages of transcription. One important modification is RNAPII ubiquitylation, which occurs in response to numerous different stimuli that cause RNAPII stalling, such as DNA damaging agents, RNAPII inhibitors, or depletion of the nucleotide pool. Stalled RNAPII triggers a so-called "last resort pathway", which involves RNAPII poly-ubiquitylation and proteasome-mediated degrad ...[more]