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Effect of dialysate potassium and lactate on serum potassium and bicarbonate concentrations during daily hemodialysis at low dialysate flow rates.


ABSTRACT:

Background

Observational studies of hemodialysis patients treated thrice weekly have shown that serum and dialysate potassium and bicarbonate concentrations are associated with patient outcomes. The effect of more frequent hemodialysis on serum potassium and bicarbonate concentrations has rarely been studied, especially for treatments at low dialysate flow rate.

Methods

These post-hoc analyses evaluated data from patients who transferred from in-center hemodialysis (HD) to daily HD at low dialysate flow rates during the FREEDOM Study. The primary outcomes were the change in predialysis serum potassium and bicarbonate concentrations after transfer from in-center HD (mean during the last 3?months) to daily HD (mean during the first 3?months).

Results

After transfer from in-center HD to daily HD (data from 345 patients, 51?±?15?years of age, mean?±?standard deviation), predialysis serum potassium decreased (P?ConclusionsControl of serum potassium and bicarbonate concentrations during daily HD at low dialysate flow rates is readily achievable; the choice of dialysate potassium and lactate concentration can be informed when transfer is from in-center HD to daily HD.

SUBMITTER: Leypoldt JK 

PROVIDER: S-EPMC6617706 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Publications

Effect of dialysate potassium and lactate on serum potassium and bicarbonate concentrations during daily hemodialysis at low dialysate flow rates.

Leypoldt John K JK   Kraus Michael A MA   Jaber Bertrand L BL   Weinhandl Eric D ED   Collins Allan J AJ  

BMC nephrology 20190709 1


<h4>Background</h4>Observational studies of hemodialysis patients treated thrice weekly have shown that serum and dialysate potassium and bicarbonate concentrations are associated with patient outcomes. The effect of more frequent hemodialysis on serum potassium and bicarbonate concentrations has rarely been studied, especially for treatments at low dialysate flow rate.<h4>Methods</h4>These post-hoc analyses evaluated data from patients who transferred from in-center hemodialysis (HD) to daily H  ...[more]

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