Ontology highlight
ABSTRACT:
SUBMITTER: Ning M
PROVIDER: S-EPMC6618095 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Ning Miaoran M Duarte Julio D JD Stevison Faith F Isoherranen Nina N Rubin Leah H LH Jeong Hyunyoung H
Clinical and translational science 20190403 4
Cytochrome P450 2D6 (CYP2D6) is a major drug-metabolizing enzyme that exhibits large interindividual variability. Recent studies suggest that differential transcriptional regulation of CYP2D6 in part may be responsible for the variability. In this study, we characterized potential determinants of CYP 2D6 transcript levels in healthy human liver tissue samples (n = 115), including genetic polymorphisms in CYP2D6 and the genes encoding transcription regulators for CYP2D6 expression; mRNA expressi ...[more]