Ontology highlight
ABSTRACT:
SUBMITTER: Sandri BJ
PROVIDER: S-EPMC6618293 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Sandri Brian J BJ Kaplan Adam A Hodgson Shane W SW Peterson Mark M Avdulov Svetlana S Higgins LeeAnn L Markowski Todd T Yang Ping P Limper Andrew H AH Griffin Timothy J TJ Bitterman Peter P Lock Eric F EF Wendt Chris H CH
The European respiratory journal 20180704 1
Chronic obstructive pulmonary disease (COPD) is a known risk factor for developing lung cancer but the underlying mechanisms remain unknown. We hypothesise that the COPD stroma contains molecular mechanisms supporting tumourigenesis.We conducted an unbiased multi-omic analysis to identify gene expression patterns that distinguish COPD stroma in patients with or without lung cancer. We obtained lung tissue from patients with COPD and lung cancer (tumour and adjacent non-malignant tissue) and thos ...[more]