Ontology highlight
ABSTRACT:
SUBMITTER: Yalak G
PROVIDER: S-EPMC6619657 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Yalak Garif G Shiu Jau-Ye JY Schoen Ingmar I Mitsi Maria M Vogel Viola V
PloS one 20190710 7
A large number of extracellular matrix proteins have been found in phosphorylated states, yet little is known about how the phosphorylation of extracellular matrix proteins might affect cell functions. We thus tested the hypothesis whether the phosphorylation of fibronectin, a major adhesion protein, affects cell behavior. Controlled in vitro phosphorylation of fibronectin by a casein kinase II (CKII) significantly upregulated cell traction forces and total strain energy generated by fibroblasts ...[more]