Ontology highlight
ABSTRACT:
SUBMITTER: Narayan R
PROVIDER: S-EPMC6619824 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Narayan Rupa R Olsson Niclas N Wagar Lisa E LE Medeiros Bruno C BC Meyer Everett E Czerwinski Debra D Khodadoust Michael S MS Zhang Lichao L Schultz Liora L Davis Mark M MM Elias Joshua E JE Levy Ron R
PloS one 20190710 7
Somatic mutations in cancer are a potential source of cancer specific neoantigens. Acute myeloid leukemia (AML) has common recurrent mutations shared between patients in addition to private mutations specific to individuals. We hypothesized that neoantigens derived from recurrent shared mutations would be attractive targets for future immunotherapeutic approaches. Here we sought to study the HLA Class I and II immunopeptidome of thirteen primary AML tumor samples and two AML cell lines (OCI-AML3 ...[more]