Ontology highlight
ABSTRACT:
SUBMITTER: Ord M
PROVIDER: S-EPMC6620034 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Örd Mihkel M Venta Rainis R Möll Kaidi K Valk Ervin E Loog Mart M
Molecular cell 20190514 1
Cyclin-dependent kinases (CDKs) coordinate hundreds of molecular events during the cell cycle. Multiple cyclins are involved, but the global role of cyclin-specific phosphorylation has remained unsolved. We uncovered a cyclin docking motif, LxF, that mediates binding of replication factor Cdc6 to mitotic cyclin. This interaction leads to phospho-adaptor Cks1-mediated inhibition of M-CDK to facilitate Cdc6 accumulation and sequestration in mitosis. The LxF motif and Cks1 also mediate the mutual i ...[more]