Ontology highlight
ABSTRACT:
SUBMITTER: Chung JM
PROVIDER: S-EPMC6620104 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Chung Jeong Min JM Sheedlo Michael J MJ Campbell Anne M AM Sawhney Neha N Frick-Cheng Arwen E AE Lacy Dana Borden DB Cover Timothy L TL Ohi Melanie D MD
eLife 20190618
Bacterial type IV secretion systems (T4SSs) are molecular machines that can mediate interbacterial DNA transfer through conjugation and delivery of effector molecules into host cells. The <i>Helicobacter pylori</i> Cag T4SS translocates CagA, a bacterial oncoprotein, into gastric cells, contributing to gastric cancer pathogenesis. We report the structure of a membrane-spanning Cag T4SS assembly, which we describe as three sub-assemblies: a 14-fold symmetric outer membrane core complex (OMCC), 17 ...[more]