Ontology highlight
ABSTRACT:
SUBMITTER: Ward A
PROVIDER: S-EPMC6620108 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Ward Anne A Hollister Jason R JR Choi Young Pyo YP Race Brent B Williams Katie K Shoup Daniel W DW Moore Roger A RA Priola Suzette A SA
PloS one 20190710 7
Prion protein (PrPC) is a protease-sensitive and soluble cell surface glycoprotein expressed in almost all mammalian cell types. PrPSc, a protease-resistant and insoluble form of PrPC, is the causative agent of prion diseases, fatal and transmissible neurogenerative diseases of mammals. Prion infection is initiated via either ingestion or inoculation of PrPSc or when host PrPC stochastically refolds into PrPSc. In either instance, the early events that occur during prion infection remain poorly ...[more]