Ontology highlight
ABSTRACT:
SUBMITTER: Siddiqui S
PROVIDER: S-EPMC6620127 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Siddiqui Sarmad S Habertheuer Andreas A Xin Yi Y Pourfathi Mehrdad M Tao Jian-Qin JQ Hamedani Hooman H Kadlecek Stephen S Duncan Ian I Vallabhajosyula Prashanth P Naji Ali A Chatterjee Shampa S Rizi Rahim R
NMR in biomedicine 20190521 8
The current standard for noninvasive imaging of acute rejection consists of X-ray/CT, which derive their contrast from changes in ventilation, inflammation and edema, as well as remodeling during rejection. We propose the use of hyperpolarized [1-<sup>13</sup> C] pyruvate MRI-which provides real-time metabolic assessment of tissue-as an early biomarker for tissue rejection. In this preliminary study, we used μCT-derived parameters and HP <sup>13</sup> C MR-derived biomarkers to predict rejection ...[more]