M⁶A Regulates Neurogenesis and Neuronal Development by Modulating Histone Methyltransferase Ezh2.

ABSTRACT: N⁶-methyladenosine (m⁶A), catalyzed by the methyltransferase complex consisting of Mettl3 and Mettl14, is the most abundant RNA modification in mRNAs and participates in diverse biological processes. However, the roles and precise mechanisms of m⁶A modification in regulating neuronal development and adult neurogenesis remain unclear. Here, we examined the function of Mettl3, the key component of the complex, in neuronal development and adult neurogenesis of mice. We found that the depletion of Mettl3 significantly reduced m⁶A levels in adult neural stem cells (aNSCs) and inhibited the proliferation of aNSCs. Mettl3 depletion not only inhibited neuronal development and skewed the differentiation of aNSCs more toward glial lineage, but also affecte

SUBMITTER: Chen J 

PROVIDER: S-EPMC6620265 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature