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Early vedolizumab trough levels predict combined endoscopic and clinical remission in inflammatory bowel disease.


ABSTRACT: Background:The relationship between vedolizumab trough levels and combined endoscopic and clinical remission is unknown. Objective:To compare vedolizumab trough levels in patients with and without combined remission within the first year of treatment. Methods:We prospectively collected vedolizumab trough levels in 51 consecutive patients (28 Crohn's disease (CD) and 23 ulcerative colitis (UC)) before all infusions up to week 22, and at weeks 38 and 54, with concentrations measured after study completion. Centrally read endoscopy was performed at a median of 46 weeks. The primary outcome was combined endoscopic (CD: Simple endoscopic score for CD (SES-CD)?

SUBMITTER: Hanzel J 

PROVIDER: S-EPMC6620872 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Early vedolizumab trough levels predict combined endoscopic and clinical remission in inflammatory bowel disease.

Hanžel Jurij J   Sever Nejc N   Ferkolj Ivan I   Štabuc Borut B   Smrekar Nataša N   Kurent Tina T   Koželj Matic M   Novak Gregor G   Compernolle Griet G   Tops Sophie S   Gils Ann A   Drobne David D  

United European gastroenterology journal 20190319 6


<h4>Background</h4>The relationship between vedolizumab trough levels and combined endoscopic and clinical remission is unknown.<h4>Objective</h4>To compare vedolizumab trough levels in patients with and without combined remission within the first year of treatment.<h4>Methods</h4>We prospectively collected vedolizumab trough levels in 51 consecutive patients (28 Crohn's disease (CD) and 23 ulcerative colitis (UC)) before all infusions up to week 22, and at weeks 38 and 54, with concentrations m  ...[more]

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