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Italian nationwide survey of pharmacologic treatments in diverticular disease: Results from the REMAD registry.

ABSTRACT: Background:Although diverticular disease is a common condition, its effective treatment is challenging in clinical practice. Objective:The objective of this article is to assess pharmacological management in different clinical settings of diverticular disease and factors associated with treatment using the Italian registry Registro Malattia Diverticolare (REMAD). Methods:At study enrolment, patients were categorised into subgroups: diverticulosis, symptomatic uncomplicated diverticular disease and previous diverticulitis. We registered demographic, clinical and lifestyle factors, quality of life and the use of treatments for diverticular disease in the last year. Logistic regression analysis assessed the association between clinical factors and treatment consumption. Results:A total of 500 of the 1206 individuals included had had at least one treatment for diverticular disease in the last year: 23.6% (166/702) of patients with diverticulosis, 55.9% (165/295) of patients with symptomatic diverticular disease, and 80.9% (169/209) of patients with previous diverticulitis (p?

SUBMITTER: Cremon C

PROVIDER: S-EPMC6620876 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Italian nationwide survey of pharmacologic treatments in diverticular disease: Results from the REMAD registry.

Cremon Cesare C Carabotti Marilia M Cuomo Rosario R Pace Fabio F Andreozzi Paolo P Barbaro Maria Raffaella MR Annibale Bruno B Barbara Giovanni G

United European gastroenterology journal 20190420 6

<h4>Background</h4>Although diverticular disease is a common condition, its effective treatment is challenging in clinical practice.<h4>Objective</h4>The objective of this article is to assess pharmacological management in different clinical settings of diverticular disease and factors associated with treatment using the Italian registry Registro Malattia Diverticolare (REMAD).<h4>Methods</h4>At study enrolment, patients were categorised into subgroups: diverticulosis, symptomatic uncomplicated ...[more]

PMID: 31316786

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Project description:BackgroundThere are little data on diverticular disease and cancer development other than colorectal cancer.MethodsWe conducted a population-based, matched cohort study with linkage of nationwide registers to the Epidemiology Strengthened by histoPathology Reports in Sweden histopathology cohort. We included 75 704 patients with a diagnosis of diverticular disease and colorectal histopathology and 313 480 reference individuals from the general population matched on age, sex, calendar year, and county. Cox proportional hazards models estimated multivariable-adjusted hazard ratios (HRs) for associations between diverticular disease and overall cancer and specific cancers.ResultsOver a median follow-up of 6 years, we documented 12 846 incident cancers among patients with diverticular disease and 43 354 incident cancers among reference individuals from the general population. Compared with reference individuals, patients with diverticular disease had statistically significantly increased overall cancer incidence (24.5 vs 18.1 per 1000 person-years), equivalent to 1 extra cancer case in 16 individuals with diverticular disease followed-up for 10 years. After adjusting for covariates, having a diagnosis of diverticular disease was associated with a 33% increased risk of overall cancer (95% confidence interval [CI] = 1.31 to 1.36). The risk increases also persisted compared with siblings as secondary comparators (HR = 1.26, 95% CI = 1.21 to 1.32). Patients with diverticular disease also had an increased risk of specific cancers, including colon cancer (HR = 1.71, 95% CI = 1.60 to 1.82), liver cancer (HR = 1.72, 95% CI = 1.41 to 2.10), pancreatic cancer (HR = 1.62, 95% CI = 1.42 to 1.84), and lung cancer (HR = 1.50, 95% CI = 1.39 to 1.61). The increase in colorectal cancer risk was primarily restricted to the first year of follow-up, and especially early cancer stages.ConclusionsPatients with diverticular disease who have colorectal histopathology have an increased risk of overall incident cancer.

Dataset Information

Italian nationwide survey of pharmacologic treatments in diverticular disease: Results from the REMAD registry.

Publications

Italian nationwide survey of pharmacologic treatments in diverticular disease: Results from the REMAD registry.

Similar Datasets

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