Ontology highlight
ABSTRACT:
SUBMITTER: Pedrola M
PROVIDER: S-EPMC6621506 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Pedrola Marina M Jorba Marta M Jardas Eda E Jardi Ferran F Ghashghaei Ouldouz O Viñas Miguel M Lavilla Rodolfo R
Frontiers in chemistry 20190704
Novel antibiotic compounds have been prepared through a selective multicomponent reaction upon the known drug Trimethoprim. The Groebke-Blackburn-Bienaymé reaction involving this α-aminoazine, with a range of aldehydes and isocyanides afforded the desired adducts in one-step. The analogs display meaningful structural features of the initial drug together with relevant modifications at several points, keeping antibiotic potency and showing satisfactory antimicrobial profile (good activity levels ...[more]