Ontology highlight
ABSTRACT:
SUBMITTER: Timmermans S
PROVIDER: S-EPMC6621919 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Timmermans Steven S Souffriau Jolien J Libert Claude C
Frontiers in immunology 20190704
Glucocorticoids (GCs) are steroid hormones widely used for the treatment of inflammation, autoimmune diseases, and cancer. To exert their broad physiological and therapeutic effects, GCs bind to the GC receptor (GR) which belongs to the nuclear receptor superfamily of transcription factors. Despite their success, GCs are hindered by the occurrence of side effects and glucocorticoid resistance (GCR). Increased knowledge on GC and GR biology together with a better understanding of the molecular me ...[more]