Ontology highlight
ABSTRACT:
SUBMITTER: Harpsoe K
PROVIDER: S-EPMC6623092 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Harpsøe Kasper K Ahring Philip K PK Christensen Jeppe K JK Jensen Marianne L ML Peters Dan D Balle Thomas T
The Journal of neuroscience : the official journal of the Society for Neuroscience 20110701 30
The neuronal α4β2 nicotinic acetylcholine receptors exist as two distinct subtypes, (α4)(2)(β2)(3) and (α4)(3)(β2)(2), and biphasic responses to acetylcholine and other agonists have been ascribed previously to coexistence of these two receptor subtypes. We offer a novel and radical explanation for the observation of two distinct agonist sensitivities. Using different expression ratios of mammalian α4 and β2 subunits and concatenated constructs, we demonstrate that a biphasic response is an intr ...[more]