Ontology highlight
ABSTRACT:
SUBMITTER: Shanmuganathan V
PROVIDER: S-EPMC6624018 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Shanmuganathan Vivekanandan V Schiller Nina N Magoulopoulou Anastasia A Cheng Jingdong J Braunger Katharina K Cymer Florian F Berninghausen Otto O Beatrix Birgitta B Kohno Kenji K von Heijne Gunnar G Beckmann Roland R
eLife 20190627
XBP1u, a central component of the unfolded protein response (UPR), is a mammalian protein containing a functionally critical translational arrest peptide (AP). Here, we present a 3 Å cryo-EM structure of the stalled human XBP1u AP. It forms a unique turn in the ribosomal exit tunnel proximal to the peptidyl transferase center where it causes a subtle distortion, thereby explaining the temporary translational arrest induced by XBP1u. During ribosomal pausing the hydrophobic region 2 (HR2) of XBP1 ...[more]