Dataset Information

Androgen Receptor Expression and Breast Cancer Survival: Results From the Nurses' Health Studies.

ABSTRACT:

Background

Hormone receptor signaling is critical in the progression of breast cancers, although the role of the androgen receptor (AR) remains unclear, particularly for estrogen receptor (ER)-negative tumors. This study assessed AR protein expression as a prognostic marker for breast cancer mortality.

Methods

This study included 4147 pre- and postmenopausal women with invasive breast cancer from the Nurses' Health Study (diagnosed 1976-2008) and Nurses' Health Study II (1989-2008) cohorts. AR protein expression was evaluated by immunohistochemistry and scored through pathologist review and as a digitally quantified continuous measure. Hazard ratios (HR) and 95% confidence intervals (CI) of breast cancer mortality were estimated from Cox proportional hazards models, adjusting for patient, tumor, and treatment covariates.

Results

Over a median 16.5?years of follow-up, there were 806 deaths due to breast cancer. In the 7?years following diagnosis, AR expression was associated with a 27% reduction in breast cancer mortality overall (multivariable HR?=?0.73, 95% CI = 0.58 to 0.91) a 47% reduction for ER+ cancers (HR?=?0.53, 95% CI = 0.41 to 0.69), and a 62% increase for ER- cancers (HR?=?1.62, 95% CI = 1.18 to 2.22) (P heterogeneity < .001). A log-linear association was observed between AR expression and breast cancer mortality among ER- cancers (HR?=?1.14, 95% CI = 1.02 to 1.26 per each 10% increase in AR), although no log-linear association was observed among ER+ cancers.

Conclusions

AR expression was associated with improved prognosis in ER+ tumors and worse prognosis in ER- tumors in the first 5-10?years postdiagnosis. These findings support the continued evaluation of AR-targeted therapies for AR+/ER- breast cancers.

SUBMITTER: Kensler KH

PROVIDER: S-EPMC6624168 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Publications

Androgen Receptor Expression and Breast Cancer Survival: Results From the Nurses' Health Studies.

Kensler Kevin H KH Poole Elizabeth M EM Heng Yujing J YJ Collins Laura C LC Glass Benjamin B Beck Andrew H AH Hazra Aditi A Rosner Bernard A BA Eliassen A Heather AH Hankinson Susan E SE Winer Eric P EP Brown Myles M Tamimi Rulla M RM

Journal of the National Cancer Institute 20190701 7

<h4>Background</h4>Hormone receptor signaling is critical in the progression of breast cancers, although the role of the androgen receptor (AR) remains unclear, particularly for estrogen receptor (ER)-negative tumors. This study assessed AR protein expression as a prognostic marker for breast cancer mortality.<h4>Methods</h4>This study included 4147 pre- and postmenopausal women with invasive breast cancer from the Nurses' Health Study (diagnosed 1976-2008) and Nurses' Health Study II (1989-2008 ...[more]

PMID: 30445651

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Project description:Fruits and vegetables contain many bioactive components that may contribute to improved survival after diagnosis of breast cancer, however, evidence to date is insufficient. We prospectively assessed the associations of postdiagnostic fruit and vegetable consumption with breast cancer-specific and all-cause mortality among 8,927 women with stage I-III breast cancer identified during follow-up of the Nurses' Health Study (NHS; 1980-2010) and NHSII (1991-2011), using a validated food frequency questionnaire completed every 4 years after diagnosis. We prospectively documented 2,521 deaths, including 1,070 from breast cancer through follow-up until 2014 in the NHS and 2015 in the NHSII. Total fruit and vegetable and total vegetable consumption was related to lower all-cause [HRQ5vsQ1, 0.82; 95% confidence interval (CI), 0.71-0.94; P trend = 0.004, and HRQ5vsQ1, 0.84; 95% CI, 0.72-0.97; P trend = 0.001, respectively], but not breast cancer-specific mortality. Total fruit consumption was not related to breast cancer-specific or all-cause mortality. Greater intake of green leafy and cruciferous vegetables was associated with lower all-cause mortality. Each 2 servings/week of blueberries was associated with a 25% (HR, 0.75; 95% CI, 0.60-0.94) lower breast cancer-specific and a 17% (HR, 0.83; 95% CI, 0.72-0.96) lower all-cause mortality. In contrast, higher fruit juice consumption was associated with higher breast cancer-specific (HRQ5vsQ1, 1.33; 95% CI, 1.09-1.63; P trend = 0.002) and all-cause mortality (HRQ5vsQ1, 1.19; 95% CI, 1.04-1.36; P trend = 0.003). Apple juice largely accounted for these higher risks and orange juice was not associated with risk. Higher postdiagnostic fruit and vegetable consumption among breast cancer survivors was not associated with breast cancer-specific mortality. However, our findings suggest that higher vegetable consumption, particularly green leafy and cruciferous vegetables, was associated with better overall survival among patients with breast cancer. Higher fruit juice consumption, but not orange juice, was associated with poorer breast cancer-specific and all-cause survival. SIGNIFICANCE: A large-scale study shows that high fruit and vegetable consumption may be associated with better overall survival among breast cancer patients, while high fruit juice consumption may be associated with poorer porgnosis.

Dataset Information

Androgen Receptor Expression and Breast Cancer Survival: Results From the Nurses' Health Studies.

Background

Methods

Results

Conclusions

Publications

Androgen Receptor Expression and Breast Cancer Survival: Results From the Nurses' Health Studies.

Similar Datasets

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