Ontology highlight
ABSTRACT:
SUBMITTER: Skvortsova K
PROVIDER: S-EPMC6624265 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Nature communications 20190711 1
Two waves of DNA methylation reprogramming occur during mammalian embryogenesis; during preimplantation development and during primordial germ cell (PGC) formation. However, it is currently unclear how evolutionarily conserved these processes are. Here we characterise the DNA methylomes of zebrafish PGCs at four developmental stages and identify retention of paternal epigenetic memory, in stark contrast to the findings in mammals. Gene expression profiling of zebrafish PGCs at the same developme ...[more]