Ontology highlight
ABSTRACT:
SUBMITTER: Mambwe B
PROVIDER: S-EPMC6624653 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Mambwe Bezaleel B Neo Kurt K Javanmard Khameneh Hanif H Leong Keith Weng Kit KWK Colantuoni Mariasilvia M Vacca Maurizio M Muimo Richmond R Mortellaro Alessandra A
Frontiers in immunology 20190705
The inflammasome is an intracellular multi-protein complex that orchestrates the release of the pro-inflammatory cytokines IL-1β and IL-18, and a form of cell death known as pyroptosis. Tyrosine phosphorylation of the inflammasome sensors NLRP3, AIM2, NLRC4, and the adaptor protein, apoptosis-associated speck-like protein (ASC) has previously been demonstrated to be essential in the regulation of the inflammasome. By using the pharmacological protein tyrosine phosphatase (PTPase) inhibitor, phen ...[more]