Ontology highlight
ABSTRACT:
SUBMITTER: Ruiz V
PROVIDER: S-EPMC6624847 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Ruiz Victor V Czyzyk Daniel J DJ Valhondo Margarita M Jorgensen William L WL Anderson Karen S KS
Bioorganic & medicinal chemistry letters 20190320 11
Protozoans of the genus Cryptosporidium are the causative agent of the gastrointestinal disease, cryptosporidiosis, which can be fatal in immunocompromised individuals. Cryptosporidium hominis (C. hominis) bifunctional thymidylate synthase-dihydrofolate reductase (TS-DHFR) is an essential enzyme in the folate biosynthesis pathway and a molecular target for inhibitor design. Previous studies have demonstrated the importance of the ChTS-DHFR linker region "crossover helix" to the enzymatic activit ...[more]