Biomarkers of collagen synthesis predict progression in the PROFILE idiopathic pulmonary fibrosis cohort.
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ABSTRACT:
SUBMITTER: Organ LA
PROVIDER: S-EPMC6624898 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
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Biomarkers of collagen synthesis predict progression in the PROFILE idiopathic pulmonary fibrosis cohort.
Organ Louise A LA Duggan Anne-Marie R AR Oballa Eunice E Taggart Sarah C SC Simpson Juliet K JK Kang'ombe Arthur R AR Braybrooke Rebecca R Molyneaux Philip L PL North Bernard B Karkera Yakshitha Y Leeming Diana J DJ Karsdal Morten A MA Nanthakumar Carmel B CB Fahy William A WA Marshall Richard P RP Jenkins R Gisli RG Maher Toby M TM
Respiratory research 20190712 1
Idiopathic pulmonary fibrosis (IPF) is characterised by excessive extracellular matrix (ECM) deposition and remodelling. Measuring this activity provides an opportunity to develop tools capable of identifying individuals at-risk of progression. Longitudinal change in markers of ECM synthesis was assessed in 145 newly-diagnosed individuals with IPF.Serum levels of collagen synthesis neoepitopes, PRO-C3 and PRO-C6 (collagen type 3 and 6), were elevated in IPF compared with controls at baseline, an ...[more]
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