Mutational landscape of the transcriptome offers putative targets for immunotherapy of myeloproliferative neoplasms.

ABSTRACT: Ph-negative myeloproliferative neoplasms (MPNs) are hematological cancers that can be subdivided into entities with distinct clinical features. Somatic mutations in JAK2, CALR, and MPL have been described as drivers of the disease, together with a variable landscape of nondriver mutations. Despite detailed knowledge of disease mechanisms, targeted therapies effective enough to eliminate MPN cells are still missing. In this study of 113 MPN patients, we aimed to comprehensively characterize the mutational landscape of the granulocyte transcriptome using RNA sequencing data and subsequently examine the applicability of immunotherapeutic strategies for MPN patients. Following implementation of customized workflows and data filtering, we identified a total of 13 (12/13 nov

SUBMITTER: Schischlik F 

PROVIDER: S-EPMC6624966 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature