Ontology highlight
ABSTRACT:
SUBMITTER: Malina J
PROVIDER: S-EPMC6625320 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Malina Jaroslav J Farrell Nicholas P NP Brabec Viktor V
Angewandte Chemie (International ed. in English) 20180607 28
The formation of triple-helical DNA is implicated in the regulation of gene expression. The triplexes are, however, unstable under physiological conditions so that effective stabilizers for the triplex formation are needed. Herein, we describe a new strategy for the stabilization of such triplexes that is based on antitumor substitution-inert polynuclear platinum complexes (SI-PPCs). These compounds were previously shown to bind to DNA through the phosphate clamp-a discrete mode of DNA-ligand re ...[more]