Ontology highlight
ABSTRACT:
SUBMITTER: Alam MW
PROVIDER: S-EPMC6625372 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Alam Muhammad Wasi MW Borenäs Marcus M Lind Dan E DE Cervantes-Madrid Diana D Umapathy Ganesh G Palmer Ruth H RH Hallberg Bengt B
Frontiers in oncology 20190705
Oncogenic receptor tyrosine kinases including anaplastic lymphoma kinase (ALK) are implicated in numerous solid and hematologic cancers. ALK mutations are reported in an estimated 9% of neuroblastoma and recent reports indicate that the percentage of ALK-positive cases increases in the relapsed patient population. Initial clinical trial results have shown that it is difficult to inhibit growth of ALK positive neuroblastoma with crizotinib, motivating investigation of next generation ALK inhibito ...[more]