A Spectrotemporal Correlate of Language Impairment in Autism Spectrum Disorder.

ABSTRACT: This study introduces an objective neurophysiological marker of language ability, the integral of event-related desynchronization in the 5-20 Hz band during 0.2-1 seconds post auditory stimulation with interleaved word/non-word tokens. This measure correlates with clinical assessment of language function in both ASD and neurotypical pediatric populations. The measure does not appear related to general cognitive ability nor autism symptom severity (beyond degree of language impairment). We suggest that this oscillatory brain activity indexes lexical search and thus increases with increased search in the mental lexicon. While specificity for language impairment in ASD remains to be determined, such an objective index has potential utility in low functioning individuals with ASD and young children during language acquisition.

SUBMITTER: Bloy L 

PROVIDER: S-EPMC6625831 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature