Bias induced by ignoring double truncation inherent in autopsy-confirmed survival studies of neurodegenerative diseases.
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ABSTRACT:
SUBMITTER: Rennert L
PROVIDER: S-EPMC6625863 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Publications
Bias induced by ignoring double truncation inherent in autopsy-confirmed survival studies of neurodegenerative diseases.
Rennert Lior L Xie Sharon X SX
Statistics in medicine 20190506 19
Neurodegenerative diseases require an autopsy for confirmation of diagnosis. When death is the event of interest, studies based on autopsy-confirmed diagnoses result in right truncated survival times because individuals who live past the end of study date do not receive a pathological diagnosis and are therefore not included in the sample. Furthermore, many studies of neurodegenerative diseases recruit subjects only after the onset of the disease, which may result in left truncated survival time ...[more]
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