Ontology highlight
ABSTRACT:
SUBMITTER: Lignitto L
PROVIDER: S-EPMC6625921 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Lignitto Luca L LeBoeuf Sarah E SE Homer Harrison H Jiang Shaowen S Askenazi Manor M Karakousi Triantafyllia R TR Pass Harvey I HI Bhutkar Arjun J AJ Tsirigos Aristotelis A Ueberheide Beatrix B Sayin Volkan I VI Papagiannakopoulos Thales T Pagano Michele M
Cell 20190627 2
Approximately 30% of human lung cancers acquire mutations in either Keap1 or Nfe2l2, resulting in the stabilization of Nrf2, the Nfe2l2 gene product, which controls oxidative homeostasis. Here, we show that heme triggers the degradation of Bach1, a pro-metastatic transcription factor, by promoting its interaction with the ubiquitin ligase Fbxo22. Nrf2 accumulation in lung cancers causes the stabilization of Bach1 by inducing Ho1, the enzyme catabolizing heme. In mouse models of lung cancers, los ...[more]