Ontology highlight
ABSTRACT:
SUBMITTER: Carlstrom KE
PROVIDER: S-EPMC6626021 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Nature communications 20190712 1
Dimethyl fumarate (DMF) is a first-line-treatment for relapsing-remitting multiple sclerosis (RRMS). The redox master regulator Nrf2, essential for redox balance, is a target of DMF, but its precise therapeutic mechanisms of action remain elusive. Here we show impact of DMF on circulating monocytes and T cells in a prospective longitudinal RRMS patient cohort. DMF increases the level of oxidized isoprostanes in peripheral blood. Other observed changes, including methylome and transcriptome profi ...[more]