Ontology highlight
ABSTRACT:
SUBMITTER: Zhou Y
PROVIDER: S-EPMC6626852 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Zhou Ya Y Zhang Yonggang Y Chen Bo B Dong Yong Y Zhang Yimeng Y Mao Bin B Pan Xu X Lai Mowen M Chen Yijin Y Bian Guohui G Zhou Qiongxiu Q Nakahata Tatsutoshi T Zhou Jiaxi J Wu Min M Ma Feng F
Stem cell reports 20190606 1
GATA2 is essential for the endothelial-to-hematopoietic transition (EHT) and generation of hematopoietic stem cells (HSCs). It is poorly understood how GATA2 controls the development of human pluripotent stem cell (hPSC)-derived HS-like cells. Here, using human embryonic stem cells (hESCs) in which GATA2 overexpression was induced by doxycycline (Dox), we elucidated the dual functions of GATA2 in definitive hematopoiesis before and after the emergence of CD34<sup>+</sup>CD45<sup>+</sup>CD90<sup> ...[more]