Ontology highlight
ABSTRACT:
SUBMITTER: Kobayashi M
PROVIDER: S-EPMC6626887 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Kobayashi Michihiro M Tarnawsky Stefan P SP Wei Haichao H Mishra Akansha A Azevedo Portilho Nathalia N Wenzel Pamela P Davis Brian B Wu Jiaqian J Hadland Brandon B Yoshimoto Momoko M
Stem cell reports 20190620 1
Precursors of hematopoietic stem cells (pre-HSCs) have been identified as intermediate precursors during the maturation process from hemogenic endothelial cells to HSCs in the aorta-gonad-mesonephros (AGM) region of the mouse embryo at embryonic day 10.5. Although pre-HSCs acquire an efficient adult-repopulating ability after ex vivo co-culture, their native hematopoietic capacity remains unknown. Here, we employed direct transplantation assays of CD45<sup>-</sup>VE-cadherin(VC)<sup>+</sup>KIT<s ...[more]