Ontology highlight
ABSTRACT:
SUBMITTER: Martinez VG
PROVIDER: S-EPMC6627023 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Martinez Victor G VG Park Danielle D Acton Sophie E SE
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20190701 1779
The great ambition to treat cancer through harnessing a patient's own immune responses has started to become reality. Clinical trials have shown impressive results and some patients reaching the end of existing treatment options have achieved full remission. Yet the response rate even within the most promising trials remain at just 30-40% of patients. To date, the focus of immunotherapy research has been to identify tumour antigens, and to enhance activation of effector lymphocytes. Yet this is ...[more]