Ontology highlight
ABSTRACT:
SUBMITTER: Garziera M
PROVIDER: S-EPMC6627128 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Garziera Marica M Roncato Rossana R Montico Marcella M De Mattia Elena E Gagno Sara S Poletto Elena E Scalone Simona S Canzonieri Vincenzo V Giorda Giorgio G Sorio Roberto R Cecchin Erika E Toffoli Giuseppe G
Cells 20190614 6
Next-generation sequencing (NGS) technology has advanced knowledge of the genomic landscape of ovarian cancer, leading to an innovative molecular classification of the disease. However, patient survival and response to platinum-based treatments are still not predictable based on the tumor genetic profile. This retrospective study characterized the repertoire of somatic mutations in advanced ovarian cancer to identify tumor genetic markers predictive of platinum chemo-resistance and prognosis. Us ...[more]