Ontology highlight
ABSTRACT:
SUBMITTER: Li Z
PROVIDER: S-EPMC6627322 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Li Ziqian Z Zhang Junjie J Zhou Jiawang J Lu Linlin L Wang Hongsheng H Zhang Ge G Wan Guohui G Cai Shaohui S Du Jun J
Cells 20190604 6
Fibroblasts become cancer-associated fibroblasts (CAFs) in the tumor microenvironment after activation by transforming growth factor-β (TGF-β) and are critically involved in cancer progression. However, it is unknown whether the TGF superfamily member Nodal, which is expressed in various tumors but not expressed in normal adult tissue, influences the fibroblast to CAF conversion. Here, we report that Nodal has a positive correlation with α-smooth muscle actin (α-SMA) in clinical melanoma and col ...[more]